Flawless Raspberry Ketone purportedly provides weight loss, energy, and overall health, without extra exercise.
Advertisements also say Flawless Raspberry Ketone prevents obesity, type 2 diabetes, and other weight-related complications.
The company is so confident in Flawless Raspberry Ketone they have given a 100% satisfaction guarantee.
Can Flawless Raspberry Ketone really do all that even with out extra exercise? I decided to find out.
What’s Under the Lid?
Flawless Raspberry Ketone has 5 ingredients supposedly connected to burning fat. However, the research might not be strong enough to verify manufacturer’s claims.
Raspberry Ketone increases adiponectin levels. Adiponectin is a hormone that controls many metabolic processes like glucose regulation and fat oxidation.
Experts find 4 days of raspberry ketone supplementation increases adiponectin levels by 77%, promoting insulin sensitivity and fat burning. 
Researchers conducted a study with a supplement containing raspberry ketone along with other ingredients. Test subjects were given the supplement for 8 weeks along with diet and exercise. Results showed weight loss and smaller waist and hip size. 
While this study is promising, raspberry ketone was only one of many ingredients so results can’t be tied directly to raspberry ketone.
There are many animal studies linking raspberry ketone to weight loss, while these are also promising they don’t guarantee the same results in humans. 
African mango contains numerous antioxidants that fight free radicals and protect the heart against damage. But, it’s the fiber-rich seed that’s attracting attention from the medical community.
Experts found patented African mango seed extract, known as IGOB131, increases adiponectin while decreasing leptin levels. These two hormones regulate fat burning and appetite, and subsequently, African mango promotes a positive improvement in body weight, body fat, and waist size. 
Acai is among the few fruits containing monounsaturated fats (MUFAS). These fats suppress appetite and promote weight loss.
A test done on 17 obese patients over 4 weeks showed MUFAS are an important part of weight loss therapy in overweight adults. 
Research shows diets getting 20 to 25 percent of calories as MUFAs result in weight loss. 
A pilot study using acai pulp found acai reduces markers in metabolic disease. After 30 days, subjects experienced a decrease in total cholesterol, fasting glucose and insulin levels, LDL-cholesterol and ratio of total cholesterol to HDL-cholesterol, as well as an increase in plasma glucose. 
Many studies show green tea induces weight loss and shrinks waist size.
In a test done on 76 obese given 420 mg caffeinated green tea, subjects experienced significant weight loss. 
In the same study, green tea with lower caffeine content was administered. This time subjects experienced smaller weight loss as well as an increase in resting energy expenditure. 
While caffeinated green tea shows the best results, decaffeinated green tea also promotes weight loss. In one study men drinking 12 cups of decaffeinated green tea lost 5.4 lbs. in 12 weeks. 
Resveratrol is a chemical found in red wine that is thought to have many health benefits.
In mice, resveratrol supplementation significantly reduced bad cholesterol while elevating good cholesterol. 
The amount of each individual ingredient or combined blend of ingredients contained in Flawless Raspberry Ketone is unknown. However, results show most of these ingredients must be taken in high quantities to be effective. Flawless Raspberry Ketone likely doesn’t contain enough of each of these ingredients to produce results.
Furthermore, most observed benefits took place in animal studies, not human ones. Researchers agree more human testing needs to happen before results can be validated.
Who Makes It?
Flawless Raspberry Ketone is made by a limited liability company called Lead Seeker. The business is new but has over 60 complaints regarding advertising and billing issues.
The company got a C- from the Better Business Bureau due to the number of complaints and unproven health claims.
Lead Seeker LLC does allow returns but do not accept returns on empty bottles. All returns must be handled through customer service at 1.855.454.4141.
Trying and Buying
It’s always good to try a product, if possible, before committing to the full product price.
Flawless Raspberry Ketone offers a 14 day trial, but be careful. The trial starts when the order is placed, so it includes shipping days. If the trial bottle isn’t returned in the 14 days, customers are charged $87.63 and sent a new bottle every month at that price.
If you want to forgo the trial and buy Flawless Raspberry Ketone, there are several options:
Flawless Raspberry Ketone has some beneficial ingredients. However, the number of complaints against the manufacturer is concerning and makes me wonder if health claims are legitimate.
Also, this product is expensive, so having a trial time is important. But, this trial option isn’t the best approach to buying a diet pill. Less than 14 days is not enough time to determine if a product really works.
While Flawless Raspberry Ketone may provide some mild results, I would not suggest this product to those looking for a fast, affordable diet pill.
 Sik Park, Kyoung. “Raspberry Ketone Increases Both Lipolysis and Fatty Acid Oxidation in 3T3-L1 Adipocytes.” Nutrition & Functional Food Research Team . Web. 12 June 2013. .
 Lopez, Hector L, Tim N Ziegenfuss, Jennifer E Hofheins, Scott M Habowski, and Shawn M Arent. “Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women.” . Journal of the International Society of Sports Nutrition . Web. 12 June 2013. .
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 Ngondi, Judith L, Blanche C Etoundi, and Julius E Oben. “IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind place.” Lipids in Health and Disease . Web. 12 June 2013. .
 Low, Cecilia C, Eric B Grossman, and Barry Gumbiner. “Potentiation of Effects of Weight Loss by Monounsaturated Fatty Acids in Obese NIDDM Patients.” Diabetes . Web. 12 June 2013. .
 Paniagua, Juan A., Angel Gallego de la Sacristana, Esther Sánchez, Inmaculada Romero, and Antonio Vidal-Puig. “A MUFA-Rich Diet Improves Posprandial Glucose, Lipid and GLP-1 Responses in Insulin-Resistant Subjects.” Journal of the American College of Nutrition . Web. 12 June 2013. .
 Udani, Jay K. “RESEARCH Open Access Effects of Açai ( Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: A pilot study.” Nutrition Journal . Web. 12 June 2013. .
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 Do, Gyeong-Min, Eun-Young Kwon, Hye-Jin Kim, Seon-Min Jeon, and Tae-Youl Ha. “Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice.” Biochemical and Biophysical Research Communications . Web. 12 June 2013. .
The third weight loss formula from ProSupps, Vanish was announced in a shroud of mystery.
According to ProSupps, Vanish will be “the most effective, innovative and COMPLETE fat burner” when it’s released this summer. Beyond that, however, ProSupps has kept their mouth shut. Even the Vanish product page on the ProSupps website is empty.
That hasn’t stopped others from gleaning information about Vanish, however. I was able to scrape up quite a bit of information about this new ProSupps product. Here’s a look at what I found.
Who’s Behind the ProSupps Brand?
ProSupps USA is a limited liability company based in Allen, Texas. Apart from a vague mission statement, however, the company doesn’t tell us much about itself.
The company appears to be relatively new, however, as nearly all products are marked as “new” and even the ones that aren’t say “coming soon” on their product pages.
We do know ProSupps is headed by T.J. Humphreys, a previous employee of Texas-based Lone Star Distribution. Humphreys was with Lone Star for 7 years and supposedly helped the company bring in $65 million in annual revenue.
It’s nice to see a company started by someone with a background in nutritional supplements rather than in business. This isn’t often the case. However, I’d still be cautious when dealing with a company that’s just getting on its feet.
You can get in touch with the company by calling 1-888-575-7301 or by emailing email@example.com. There’s also a contact form available on ProSupps.com.
What Ingredients Are in Vanish?
Because Vanish’s product page literally vanished from the ProSupps.com website, I had to seek out alternative information sources on the Vanish formula. What I found was a list of ingredients divided into 3 blends: the Fat-Burning Matrix, the Euphoria Matrix, and the Appetite Control Matrix.
There is currently no information on either individual ingredient amount or the overall formula size. Judging by other products from ProSupps, the company will reveal the overall blend size and not individual ingredient amounts when Vanish is released.
Until then, I have to satisfy myself with analyzing the ingredients in Vanish.
The Fat-Burning Matrix
The Fat-Burning Matrix is meant to eliminate excess fat mass primarily through central nervous system stimulants. Many of these ingredients are effective, though without knowing individual amounts, it’s impossible to say if they’ll be effective here.
Perhaps the most ubiquitous diet pill ingredient, caffeine is a central nervous system stimulant that increases both energy production and caloric burn. Both benefits aid weight loss.
In a 1978 study, subjects taking caffeine prolonged their workouts by an average 15 minutes . By working out longer and harder, you increase caloric burn and create the caloric deficit needed to lose weight.
A 1994 study revealed further fat-burning properties in caffeine. In this study, overweight and obese women taking caffeine saw a significant decrease in BMI and an increase in metabolic rate . Thus, caffeine both directly and indirectly supports weight loss.
Green Tea Extract
Green tea is another weight loss perennial. In addition to its fat-burning caffeine content, green tea also contains catechins, which stimulate the body to expend calories and decrease body fat.
According to a 2005 study in the American Journal of Clinical Nutrition, drinking enough green tea over an extended time period reduces waist size, BMI, and total body fat . Green tea also contains antioxidants that support proper digestion, helping you absorb more nutrients from food and stay healthy while dieting.
Raspberry ketone is a chemical from red raspberries thought to induce weight loss. The extract became popular after it was featured on “The Dr. Oz Show” in February 2012. The supporting study behind raspberry ketone’s use as a fat burner took place in 2004 and involved overweight mice. At the study’s end, mice fed raspberry ketone had a significantly lower fat mass than mice in the control group .
Although this led Dr. Oz to label raspberry ketone a “miracle fat burner,” I won’t be so convinced until I see these results replicated in humans.
A pyruvic acid and calcium combination, calcium pyruvate is said to aid the conversion sugar and starch into energy. This is believed to enhance metabolism and energy production. When paired with a sensible diet and regular exercise, these benefits supposedly support weight loss.
Unfortunately, scientific studies don’t support this hypothesis. In a 1999 study, no significant differences in metabolic response or body composition were found in male subjects taking calcium pyruvate . These disappointing results were echoed again in 2005 in a study observing calcium pyruvate supplementation in women .
Aegeline is an alkaloid of bael leaves and is most commonly used to treat digestive problems. However, as an anti-inflammatory, aegeline may also have benefits. Overweight and obese people have inflamed fat cells, which could be treated with an anti-inflammatory.
However, aegeline has no direct fat-burning properties, so it’s hard to see why it’s included in Vanish’s Fat-Burning Blend.
Another alkaloid, hordenine is related to phenylethylamine (PEA) and is said to trigger greater action in the central nervous system. If true, this supports hordenine’s classification as a fat burner.
However, there are next to no scientific reports on hordenine’s weight loss benefits. Though it was found to increase blood pressure in test animals, hordenine supplementation didn’t lead to weight loss.
Instead, hordenine’s primary effects on test animals were disturbances in the cardiovascular, respiratory, and nervous systems . Knowing this, I’m not sure why hordenine is in Vanish.
The Euphoria Matrix
There’s no information on what the Euphoria Matrix is supposed to do, but I can only assume it’s included to alleviate stress and boost mood.
Rhodiola rosea root is considered an “adaptogen,” which means it enhances the body’s response to physical, chemical, and environmental stress. With less stress, mood improves and high cortisol levels—which contribute to increased belly fat—recede.
Rhodiola was tested and proven effective in a 2000 study involving students during an examination period. A group of students was given rhodiola while a second group was given a placebo. Both were monitored for common mental stress markers. At the study’s end, students taking rhodiola were significantly less stressed than students taking a placebo .
Alpha Lipoic Acid (ALA)
ALA protects against oxidative stress—the removal of electrons from an atom or molecule resulting in damaged cells and compromised body processes. In a 2009 study, researchers verified ALA protects organs from oxidative stress and free radicals, particularly in patients with metabolic syndrome .
This is good to know, but it doesn’t do anything to directly alleviate mental stress and improve mood.
A precursor to serotonin production, 5-HTP improves mood and eases stress. 5-HTP also increases melatonin production, which regulates and improves the sleep cycle.
This may seem incidental to weight loss, as lack of sleep increases hunger-causing hormones and leads to weight gain. For effective weight loss, Arizona-based sleep clinic director Michael Breus recommends getting 7.5 hours of sleep each night . If you’re having trouble meeting that minimum, 5-HTP may help.
Appetite Control Matrix
Finally, the Appetite Control Matrix increases satiety and decreases hunger cravings that may be sabotaging your diet.
Dandelion is a safe and effective diuretic that cleanses the system and may trigger some initial water weight loss. It’s also rich in vitamins and minerals that treat gastrointestinal upset.
However, there is no direct evidence dandelion increases satiety or fights hunger. Initial findings from animal studies suggest dandelion may normalize blood sugar, which has a positive effect on appetite control . Unfortunately, these results are not verified and haven’t been tested in humans.
Often used as a fat burner, yohimbe bark may also have appetite suppressing properties. In one study, subjects who took yohimbe experienced less hunger and lower overall calorie intake than subjects taking a placebo .
Moreover, while yohimbe reduced carb and fat intake, it didn’t neutralize protein intake. Because protein increases satiety, this is a particularly exciting study.
A common anxiety treatment, rauwolfia calms the brain and body, which decreases cortisol production. While less cortisol doesn’t lead to fat burning, it does prevent future weight gain by limiting stress. In a 1953 academic paper, scientists note rauwolfia may also treat high blood pressure .
It seems rauwolfia may fit better in the Euphoria Blend.
I like that Vanish approaches weight loss from so many different angles. However, I wish they would have done so with more innovated ingredients. While caffeine and green tea are certainly effective, ingredients like raspberry ketone—while popular—are less reliable.
Furthermore, while I like diet pills that aim to boost mood in addition to metabolism, I’m not sure the Euphoria Blend is the best use of space in an already crowded diet pill.
Obviously, nothing can really be known until Vanish is released and individual ingredient amounts are revealed.
Is Vanish Expensive?
The only pricing information I could find on Vanish listed the regular price as $64.99. Through i-Supplements.com, however, you can buy 1 bottle for $38.99 or 2 for $75.99.
It’s too early to say if this is the best deal on Vanish, as i-Supplements is among the only websites to list Vanish.
When Will It Be Available?
Multiple sources place Vanish’s release date sometime in June 2013. Keep checking back for more up-to-date information through ProSupps.com, or supplement news websites like Stack3d.com.
Should You Wait For Vanish?
Without more information on ingredient amount, it’s hard to make a judgment call on Vanish. However, the ingredient list hasn’t convinced me Vanish is anything other than a generic weight loss formula with some extra—and probably unnecessary—padding.
If you’re still interested in Vanish, I recommend waiting until more is revealed on this product, and even until customer reviews start cropping up. With a new company like ProSupps, you want to be careful where you spend your money.
 Costill, D.L., G.P. Dalsky, and W.J. Fink. 1978. Effects of caffeine ingestion on metabolism and exercise performance. Medicine and Science in Sports: Vol. 10, Issue 3.
 Yoshida, T., N. Sakane, T. Umekawa, and M. Kondo. 1994. Relationship between basal metabolic rate, thermogenic response to caffeine, and body weight loss following combined low calorie and exercise treatment in obese women. International Journal of Obesity and Related Metabolic Disorders: Vol. 18, Issue 5.
 Nagao, Tomonori. Yumiko Komine, Satoko Soga, Shinichi Meguro, Tadashi Hase, Yuiktaka Tanaka, and Ichiro Tokimitsu. 2005. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. American Journal of Clinical Nutrition: Vol. 81, Issue 1.
 Morimoto, C., Y. Satoh, M. Hara, S. Inoue, and T. Tsujita. 2005. Anti-obese action of raspberry ketone. Life Sciences: Vol. 77, Issue 2.
 Stone, M.H., K. Sanborn, L.L. Smith, H.S. O’Byant, T. Hoke, A.C. Utter, R.L. Johnson, R. Boros, J. Hruby, K.C. Pierce, M.E. Stone, and B. Garner. 1999. Effects of in-season (5 weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. International Journal of Sport Nutrition: Vol. 9, Issue 2.
 Koh-Banerjee, Pauling, Maria Ferreira, Mike Greenwood, Rodney Bowden, Patty Cowan, A.L. Almada, and Richard Kreider. 2005. Effects of calcium pyruvate supplementation during training on body composition, exercise capacity, and metabolic responses to exercise. Nutrition: Vol. 21, Issue 3.
 Camus, L. 1906. Action de sulfate d’hordenine sure circulatin. Comptes Rendus Chimie: Vol. 142, 237.239.
 Spasov, A.A., G.K. Wikman, V.B. Mandrikov, I.A. Mironva, and V.V. Neumoin. 2000. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regiment. Phytomedicine: Vol. 7, Issue 2.
 Gianturco, V., A. Bellomo, E. D’Ottavio, V. Formosa, A. Iori, M. Mancinella, G. Troisi, and V. Marigliano. Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction? Archives of Gerontology and Geriatrics: Vol. 49, Issue 1.
 Mann, Denise. 2013. Sleep and Weight Gain. Will better sleep help you avoid extra pounds? WebMD.com: http://www.webmd.com/sleep-disorders/excessive-sleepiness-10/lack-of-sleep-weight-gain.
 University of Maryland Medical Center. 2013. Dandelion. UMM.edu: http://www.umm.edu/altmed/articles/dandelion-000236.htm.
 Halton, Thomas and Frank Hu. 2004. The effects of high protein diets on thermogenesis, satiety, and weight loss: A critical review. Journal of the American College of Nutrition: Vol. 23, Issue 5.
 Anderson, T. and J. Fogh. 2001. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. The Journal of Human Nutrition and Dietetics: The Official Journal of the British Dietetic Association: Vol. 14, Issue 3.
Novex Biotech ThermoDyne
A longtime member of the weight loss community, Novex Biotech says they’ve finally found the solution to powerful fat burning without ephedra: ThermoDyne.
ThermoDyne is a new 3-pronged diet pill from Novex Biotech said to oxidize lipids, burn fat, and improve energy. With a 1-gram formula, ThermoDyne is packed with herbal extracts and other ingredients said to support weight loss efforts in the most powerful way possible.
Novex Biotech does have an impressively lengthy history in the weight loss industry, but experience doesn’t always bring wisdom. To see if ThermoDyne represents a thoughtful foray into potent weight loss or a quick way to make some more cash, I looked into this diet pill further.
The ThermoDyne Formula
The ThermoDyne formula features two proprietary blends, each designed to support weight loss through different means. The Fat-Burning Blend oxidizes fat and lowers fat mass, while the Energy Blend stimulates the central nervous system to improve metabolic rate and increase energy.
To determine if this system is effective, I’ll look at the ingredients in each blend.
Fat-Burning Blend (509 mg)
Conjugated Linoleic Acid (CLA)
Said to trigger fat loss without affecting muscle mass, CLA works without affecting the central nervous system. This makes it ideal for people sensitive to stimulants. However, in a stimulant-laden diet pill like ThermoDyne, it doesn’t make much difference.
CLA has been studied and proven effective for weight loss . Unfortunately, many studies yielded mixed results or only modest fat loss benefits.
Better known as orange extract, citrus sinensis has plenty of health properties, but no direct relation to weight loss. However, as a fiber source, citrus sinensis may improve satiety and ward off pesky hunger cravings.
Citrus sinensis also contains 140 percent of daily recommended vitamin C intake, which improves metabolism and supplies antioxidant to fight off toxins released during fat breakdown .
Another citrus extract, citrus paradisis is actually grapefruit. Because grapefruit lowers blood sugar, it’s believed to ward off hunger cravings and prevent overeating.
These effects were proven in a 2006 study in which subjects eating half a grapefruit before meals lost .3 more pounds than subjects who did not . Unfortunately, these results are modest and not much of a game changer in a diet.
Known as sweet orange, citrus macracantha is the third and last citrus extract in ThermoDyne. Unfortunately, it is also the least effective. Thought citrus macracantha is advertised as the replacement for ephedra, there is no scientific or even anecdotal evidence linking this extract with weight loss .
Perhaps Novex Biotech was thinking of citrus aurantium, or bitter orange, which has a similar chemical structure to ephedra. If this is the case, it makes Novex Biotech either ignorant or deceptive.
Salix alba is better known as white willow, which carries the nickname “nature’s aspirin” due to its anti-inflammatory properties. Because fat cells in overweight and obese people are often inflamed, white willow could prove useful.
Additionally, white willow is linked with a decrease in muscle pain and soreness, which could improve workout recovery . However, there is no evidence white willow plays a direct role in weight loss.
You may know this ingredient as coleus forskohlii, an herbal extract with fat loss properties. Coleus forskohlii contains forskolin, a chemical compound believed to reduce fat mass while preserving and even building muscle.
These benefits were proven in a 2005 study in which subjects taking forskolin saw their fat mass and body fat percentage decrease significantly .
Last and possibly least, tribulus terrestris is an herbal extract often recognized for its ability to promote greater testosterone production. While testosterone is linked with better body composition, however, tribulus terrestris has never proven useful in weight loss .
Energy Blend (493 mg)
The Energy Blend seems to be a little more effective, relying on stimulants to trigger greater action in the central nervous system and improve metabolic rate and energy production. Together, these 4 ingredients comprise nearly half the ThermoDyne formula.
Coffee arabica is a Middle-Eastern coffee shrub with a high caffeine concentration. Due to this caffeine content, coffee arabica stimulates the central nervous system to increase metabolic rate and accelerate fat burning.
It also improves energy levels. In a 1978 study, subjects taking caffeine exercised an average 15 minutes longer than subjects who did not .
Better known as guarana, paullinia sorbilis is a South American herbal extract that, like coffee arabica, contains a lot of caffeine. However, guarana has one advantage over caffeine. As a fatty substance, it dissolves slowly, preventing a “caffeine crash.”
Guarana is also linked with weight loss. In one study, subjects who took guarana alongside other herbal extracts lost 11.2 pounds in 45 days . However, because ThermoDyne doesn’t contain these other extracts, I can’t say whether guarana produces the same results in this formula.
Cocoa, or themobroma cacao, is an antioxidant-rich ingredient that lowers blood pressure and fights free radicals. In addition to promoting a healthy immune system, cocoa also has weight loss properties.
Though it hasn’t yet been tested in humans, rats fed theobroma cacao lost significant body and fatty tissue weight .
Rounding out the formula is sterculia acuminata, or kola nut. Like the other ingredients in the Energy Blend, kola nut owes its effectiveness to a high caffeine concentration.
When taken in the recommended amount, kola nut improves metabolism and increases calorie burning . It is said to do so without sacrificing muscle tone.
It seems Novex Biotech hasn’t done anything really original here after all. While the citrus ingredients are a unique addition to ThermoDyne, this formula essentially relies on large amounts of caffeine as well as non-stimulants like CLA and forskolin. This isn’t bad, necessarily, but there’s nothing innovative about this approach.
Another issue is the lack of explicit ingredient amount information. While each blend is large enough to potentially contain the recommended dosage for each ingredient, Novex Biotech doesn’t assure us this is the case. Instead, we’re left guessing without any customer reviews to shed light on the matter.
If I had to guess, I’d say ThermoDyne provides extra energy and support to an already-developed weight loss plan.
The ThermoDyne Study
ThermoDyne is unique in that Novex Biotech has paid to have the entire formula studied.
According to manufacturers, the study lasted 12 weeks and involved 20 overweight volunteers with an average 28.3 BMI. The subjects were divided into 2 groups of 10. One group was given the fat-burning complex in ThermoDyne and the other received a sugar pill placebo.
During the study, subject were told not to diet and continued to consume 1500-2000 kcal/day and exercised daily.
At the end of the study, the group taking ThermoDyne lost 15.6% body fat—a significant improvement over the placebo group.
Unfortunately, the details of this study are not available for us to see, and the study isn’t published by a third-party source. In fact, we have no information about who performed the ThermDyne study. However, it’s pretty safe to say they were compensated, which makes it difficult to fully trust this study.
Furthermore, a sample size as small as 20 people could easily be wrong. It’s nice to see a formula that’s been studied, but I’d have to see a larger study conducted by a third-party to fully trust these results.
Possible Side Effects
ThermoDyne is supposedly so powerful it may prove dangerous to some users. Novex Biotech recommends people with high blood pressure, diabetes, and psychosis avoid ThermoDyne, as well as people taking MAO inhibitors. In fact, ThermoDyne is supposed to be for people in “overall good health.”
Of course, this presents something of a problem as most people looking to lose weight won’t be in “overall good health” until they’ve done so.
Novex Biotech doesn’t give any more specific information on side effects, but the ingredients in the formula suggest the following side effects may be possible:
• Nervousness or anxiety
• Stomach Irritation
• Nausea and vomiting
• Increased heart rate
• High blood pressure
• Rapid breathing
• Stomach cramps
Obviously, in individuals with pre-existing health concerns, these side effects may lead to serious complications. For most people, however, they’ll be a minor annoyance.
To limit these side effects, avoid taking ThermoDyne within 5 hours of bedtime. Don’t take ThermoDyne with other caffeine-infused stimulants like coffee or soda.
If you have any remaining concerns, talk with your doctor before starting ThermoDyne. This is an especially good idea if you currently have high blood pressure or heart issues.
Purchasing Options for ThermoDyne
The only place to buy ThermoDyne right now is through NovexBiotech.com or GNC.com. There, you can get a 1-month supply for $59.99 or save $12.00 with a GNC Gold Card. You can also buy 2 bottles for $90.00 under GNC’s “buy one, get one 50% off” deal.
Because ThermoDyne is a new product, its availability has not yet expanded. Perhaps with time, you’ll have more options on retailers and pricing. For now, however, you’ll pay an average price for an average diet pill.
Making a Decision on Novex Biotech ThermoDyne
Despite its advertisements, Novex Biotech created a fairly standard diet pill in ThermoDyne. While it has some unusual ingredients, ThermoDyne relies on high caffeine content and a few supporting ingredients to increase metabolism and create energy.
Instead of buying this diet pill, I recommend looking for something a little more innovative and more forthcoming about its active ingredients.
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 Costill, D.L., G.P. Dalsky, and W.J. Fink. 1978. Effects of caffeine ingestion on metabolism and exercise performance. Medicine and Science in Sports: Vol. 10, Issue 3.
 Zenk, John, Sandra Leikam, Laurie Kassen, and Michael Kuskowski. 2005. Effect of Lean System 7 on metabolic rate and body composition. Nutrition: 179-185.
 Matsui, N., R. Ito, E. Nishimura, M. Yoshikawa, M. Kato, M. Kamei, H. Shibata, I. Matsumoto, K. Abe, and S. Hashizume. 2005. Ingested cocoa can prevent high-fat diet-induced obesity by regulating the expression of genes for fatty acid metabolism. Nutrition: Vol. 21, Issue 5.
 WebMD. 2013. Cola Nut. Accessed 21 May 2013. http://www.webmd.com/vitamins-supplements/ingredientmono-937-Sterculia+acuminata+COLA+NUT.aspx?activeIngredientId=937&activeIngredientName=Sterculia+acuminata+%28COLA+NUT%29&source=2.
BioGenetic Laboratories HCG Activator
HCG Activator “offers new hope for dieters,” according to BioGenetic Laboratories.
But what is this new hope?
Supposedly, HCG Activator allows you to “enjoy the powerful effects of HCG without the costly, painful injections.” HCG, or human chorionic gonadotropin, is a pregnancy hormone that supposedly “allows the body to burn excess body fat by using that fat as a food source.”
HCG Activator encourages you to follow the enclosed HCG diet plan and take the supplement for ultimate weight loss results.
It’s important to examine whether this process actually causes significant weight loss. Plus, HCG Activator may be on the pricier side, so we need to determine whether it’s worth the cost.
What’s In HCG Activator?
Many customers claim to have lost amazing amounts of weight on the HCG diet. Unfortunately, the HCG diet is largely disproven in studies.  In addition, the extremely low-calorie intake encouraged by the diet could damage health. 
But, does HCG Activator itself cause weight loss?
Supposedly, HCG Activator ingredients support HCG production and fat burning.
Firstly, HCG Activator contains two amino acids: arginine and ornithine. Arginine improves blood flow,  and ornithine is used by some to improve athletic performance.  Both amino acids have an effect on hormones, but there is no proof they activate HCG.
Additionally, HCG Activator includes two ingredients that influence brain chemicals, potentially making dieting easier.
Huperzine A, for example, increases the chemical acetylcholine.  Those with low acetylcholine crave fat, since fat provides choline, an acetylcholine building block. 
Furthermore, black cohosh affects serotonin, which contributes to feelings of wellbeing, perhaps making dieters less likely to crave eating for pleasure. 
Similarly, saffron may increase fullness, making dieters less likely to overeat. 
Finally, HCG Activator also includes two fat burning ingredients: carnitine and green tea.
Carnitine given to mice improved fat metabolism and improved female hormone development. 
Green tea also reduced fat, blood pressure, and cholesterol in obese men and women. 
While these ingredients may support a weight loss plan, they are not proven to affect HCG levels.
Is HCG Activator Safe?
HCG Activator shouldn’t cause serious side effects. However, some ingredients cause minor side effects such as nausea, headache, allergic reaction, drowsiness, anxiety, change of appetite, and bloating.
Following the HCG diet, however, may be dangerous. Restricting calories to such an extreme could cause irregular heartbeat, electrolyte imbalance, or gallstone formation. 
What Do People Think About HCG Activator?
The following comments from users on Amazon.com can give us an idea of how HCG Activator was received:
• “I love love love this diet and I love this product! I did the diet and went to a doctor to administer the hcg two times, which costed $600 a month. Each time I lost over 30lbs so I was skeptical about buying hcg in a pill form without an M.D but I tried anyway and it’s working even better than the doctor’s hcg.” (Rolando A. Edwards)
• “These work and they work fast I’m not sure how much I lost but I did lose some weight and people noticed I was loving these pills!!!… Only problem is they broke my face out. :-(“ (SuesueMama)
• “It was with great expectation I bought the hgc activator. I am now a week and a half into it with no loss. The worse part is the huge craving at 5pm every afternoon.” (Osla Thomason)
How Do You Take HCG Activator?
While following the enclosed diet plan, HCG Activator users are encouraged to take one serving (2 capsules) twice daily with a glass of water. Take one serving upon waking and another six hours later.
Should You Buy HCG Activator?
HCG Activator is sold at GNC.com for $79.99 and at Amazon.com for $52.99. On one hand, this is much cheaper than HCG injections. On the other hand, there’s no proof this supplement increases HCG levels.
Due to the unproven nature of this supplement and the potential dangers involved with the diet, I suggest you choose a different diet pill.
 GK Lijesen et al. “The effect of human chorionic gonadotropin (HCG) in the treatment of obesity by means of the Simeons therapy: a criteria-based meta-analysis.” Br J Clin Pharmacol. 1995; 40 (3): 237-243. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365103/
 Jennifer K. Nelson. “Does the HCG diet work – and is it safe?” MayoClinic.com. Available from: http://www.mayoclinic.com/health/hcg-diet/an02091
 “L-Arginine.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-875-arginine.aspx?activeIngredientId=875&activeIngredientName=arginine&source=1
 “Ornithine.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-200-ORNITHINE.aspx?activeIngredientId=200&activeIngredientName=ORNITHINE
 “Huperzine A.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-764-huperzine.aspx?activeIngredientId=764&activeIngredientName=huperzine&source=1
 Jade Teta. “Is Your Brain Making You Fat?” MetabolicEffect.com. Available from: http://www.metaboliceffect.com/is-your-brain-making-you-fat/#
 “Black Cohosh.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-857-Cohosh+Negro+BLACK+COHOSH.aspx?activeIngredientId=857&activeIngredientName=Cohosh+Negro+(BLACK+COHOSH)&source=2
 Gout B, Bourges C, Paineau-Dubreuil S. “Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women.” Nutr Res. 2010; 30 (5): 305-13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20579522
 Dunning KR et al. “Increased beta-oxidation and improved oocyte developmental competence in response to l-carnitine during ovarian in vitro follicle development in mice.” Biol Reprod. 2011; 85 (3): 548-55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21613630
 Tomonori Nagao et al. “A Green Tea Extract High in Catechins Reduces Body Fat and Cardiovascular Risks in Humans.” Obesity. 2007; 15 (6): 1473-1483. Available from: http://onlinelibrary.wiley.com/doi/10.1038/oby.2007.176/full
BioGenetic Laboratories gcb LEAN
BioGenetic Laboratories clearly created gcbLEAN according to the golden rule of the weight loss industry: if Dr. Oz recommends it, it sells.
gcbLEAN is a 2-ingredient diet pill featuring raspberry ketone and green coffee bean. These 2 ingredients shot onto the weight loss scene in 2012 when Dr. Oz featured them on his syndicated television program. Sales have been through the roof ever since.
But is Dr. Oz right about these ingredients?
Most people know not to trust everything they hear on television, but sometimes the desire to lose weight overpowers intellect. Before you jump on the gcbLEAN bandwagon, let’s find out a little more about this product.
Is the gcbLEAN Formula a Good One?
BioGenetic Laboratories says the combination of green coffee bean and raspberry ketone is so powerful it can help you lose weight without diet and exercise.
This seems fishy to me, but let’s see what these ingredients have to offer before we consider the likelihood of that statement.
Green Coffee Bean (800 mg)
Green coffee bean is simply unroasted black coffee bean. Still retaining the stimulant-like properties of black coffee bean, green coffee is said to be a better choice for weight loss due to the high chlorogenic acid content.
Chlorogenic acid is believed to support weight loss goals in addition to fighting diabetes, heart disease, and other weight-related complications.
The go-to study took place in 2012 when researchers observed subjects taking green coffee bean. At the end of 12 weeks, subjects lost an average 17 pounds . However, this study involved just 16 people, making green coffee’s effectiveness a little iffy.
Raspberry Ketone (100 mg)
Raspberry ketone is a chemical in red raspberries believed to aid weight loss by boosting metabolism and supporting healthy adiponectin levels. Unfortunately, there is even less supporting evidence on raspberry ketone than there is on green coffee bean.
The only supporting study on raspberry ketone took place in 2004 and measured raspberry ketone’s effect on overweight mice. While the mice fed raspberry ketone lost significantly more weight than those in a control group, it would be nice to see a human study to back up these results .
Let’s start with the pros: green coffee bean and raspberry ketone are both included in their recommended dosages and may have some effect on weight loss. Together, they approach appetite suppression and fat burning in similar and complementary ways.
The cons: raspberry ketone has never been tested in humans, and is therefore an unreliable ingredient. Additionally, the lack of diversity in the gcbLEAN formula worries me. If raspberry ketone is ineffective, you’re essentially relying on green coffee bean to help you lose weight.
Unsurprisingly, there’s nothing here that makes me believe gcbLEAN can help you lose weight without diet and exercise. While this formula could very well support existing weight loss efforts, I don’t believe this is a miracle supplement.
Could It Cause Side Effects?
Although gcbLEAN is advertised as a stimulant-free diet pill, the caffeine in green coffee bean may still affect sensitive users. Similarly, raspberry ketone is sometimes considered a stimulant, which means it may bother some users.
Although gcbLEAN seems to be largely side-effect free, the following side effects are still a possibility.
• Jitters and tremors
• Headache and nausea
• Nervousness and anxiety
• Increased blood pressure
• Rapid, pounding heartbeat
Again, these side effects are unlikely to plague most users. However, if you are particularly sensitive to stimulants, you may have some problems with gcbLEAN. If you’re concerned, talk to your doctor about how gcbLEAN will affect your health before starting gcbLEAN.
What’s the Best Way to Use gcbLEAN?
gcbLEAN is meant to be taken twice a day, 2 capsules at a time, for a total of 4 capsules daily. This is a slightly higher dosage than many diet pills require but is necessary to get the full recommended dosages of both raspberry ketone and green coffee bean.
BioGenetics Laboratories recommends taking 1 serving upon waking, before breakfast. Take the second serving 6 hours later, between lunch and dinner.
While advertisements say gcbLEAN works without changes to diet or exercise habits, it’s best to accompany gcbLEAN with a formal weight loss program. If you need ideas, a diet plan formulated by BioGenetics Laboratories comes with your gcbLEAN order.
How Much Does gcbLEAN Cost?
While the convenience of having the correct dosages of green coffee and raspberry ketone in one product is nice and worth paying a little extra for, I can’t condone the $49.99 price tag on gcbLEAN.
The bottle lasts one month and is simply a combination of 2 ingredients. The convenience cost here is too high.
Luckily, there are a few alternative purchasing options. The best deals I found on gcbLEAN include:
While these prices are definitely better, I still don’t think gcbLEAN is worth most of them. If you can find prices like those offered on Tiger Fitness and NSM Sport, however, you may get your money’s worth.
Should You Try BioGenetic Laboratories gcbLEAN?
Unless you’re on a tight budget, I don’t see any reason not to try gcbLEAN. Its formula certainly can’t live up to many of its more outrageous advertising claims, but it’s still a solid product with good ingredients.
If you’re looking for a supplement that builds on the foundation you’ve created with your weight loss plan, gcbLEAN is a good choice. Just don’t expect something for nothing.
 Vinson, Joe, Bryan Burnham, and Mysore Nagendra. 2012. Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes, Metabolic Syndrome, and Obesity: Targets and Therapy: Vol. 5, Issue 1.
 Morimoto, C., Y. Satoh, M. Hara, S. Inoue, and T. Tsujita. 2005. Anti-obese action of raspberry ketone. Life Sciences: Vol. 77, Issue 2.
Cupuacu fruit smells like a mixture of chocolate and pineapple, and it tastes like a pear with a hint of banana. Could a fruit that sounds this enticing really help you lose weight? Cupuacu Pure manufacturers think so.
Advertisements claim this fruit—in supplement form—is a potent fat burner that suppresses appetite and improves immune system.
Of course, over-the-top weight loss claims always make me a bit wary, so I looked closer into Cupuacu Pure to see if it could live up to these tremendous assertions.
Capuacu recently emerged in the nutrition scene as a must-have superfruit. In fact, Mintel, a market research organization, recently predicted capuacu would be the next big superfruit flavor. 
Capuacu comes from a rainforest tree related to cacao. It contains several flavonoid antioxidants, which protect cells from damaging free radicals. 
It also contains theacrine, an alkaloid with anti-inflammatory activities.  Inflammation increases risk of obesity and other health complications, so presumably theacrine could play a role in reducing these symptoms.
But is capuacu a weight loss wonder? Probably not.
Although the manufacturers claim cupuacu’s results are backed by science, there is no clinical evidence cupuacu promotes weight loss.
Does Cupuacu Pure Come from a Reliable Company?
Capuacu Pure is supposedly manufactured by Natural Nutrition, but there are several companies with this name, so locating the exact source is difficult.
However, based on the Cupuacu Pure website, I’m not inclined to trust the company. The product information is riddled with typos, and links to scientific studies are not provided.
How Do You Buy Cupuacu Pure?
You can buy the following supplies of Cupuacu Pure at CupuacuPure.com:
• 1 month (1 bottle free): $37
• 2 months (2 bottles free): $67
• 3 months (4 bottles free): $97
Apparently, the product comes with a 100% guarantee, but there is no indication as to how to return the product. Fortunately, you can contact the company with questions at 1-800-291-4798.
What Do Consumers Think about Capuacu Pure?
As there are no unbiased customer reviews available, it’s impossible to say how Capuacu Pure works on users. This is definitely a warning sign.
Does Capuacu Pure Have Side Effects?
Presumably Capuacu Pure does not cause side effects, since it supposedly contains pure capuacu extract. However, since ingredients aren’t listed, there may be other ingredients and fillers we’re not aware of, and in that case, it’s hard to say whether Capuacu Pure is safe.
Capuacu Pure: Weight Loss Wonder?
Capuacu Pure contains an interesting and rare superfruit. But, there’s no scientific evidence this fruit—or this diet pill—aids weight loss.
There are also no reliable customer reviews, no company background information, and a high price with a vague money back guarantee. For these reasons, I would pass on Capuacu Pure.
 Caroline Scott-Thomas. “Mintel picks cupuacu as next big superfruit flavor.” 23 Nov 2009. Available from: http://www.foodnavigator-usa.com/Ingredients/Flavors-and-colors/Mintel-picks-cupuacu-as-next-big-superfruit-flavor
 Hui Yang et al. “New Bioactive Polyphenols from Thobroma grandiflorum (“Cupuacu”).” J. Nat. Prod. 2003; 66 (11): 1501-1504. Available from: http://pubs.acs.org/doi/abs/10.1021/np034002j
 Wang Y. et al. “Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities.” Fitoterapia. 2010; 81 (6): 627-31. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20227468
Nutrition 53 Lean1
Nutrition 53 Lean1 isn’t just your average healthy performance shake, advertisements say. It’s packed with not only protein and vitamins, but also fruits and vegetables, including several claimed to jumpstart weight loss.
With so much nutritional content in one shake, I was curious as to whether Lean1 could be used as a healthy meal replacement to promote weight loss.
Nutrition 53 Lean1 Nutrition Facts
Lean1 boasts 220 calories per serving, with 20 g protein and 5 g fiber, all solid amounts for a weight loss shake. But Lean1 also has 11 g sugar, more than other weight loss shakes.
Consuming too much sugar causes weight gain along with other health problems, so the American Heart Association suggests limiting added sugars to no more than half your daily caloric intake.  While the sugar content in Lean1 contributes significantly to your daily sugar intake, it shouldn’t be detrimental if Lean1 is used as part of a low-sugar diet.
Nutrition 53 Lean1 Ingredients
Lean1 has three categories of ingredients: N53 Protein Blend, N53 Fruit & Vegetable Blend, and N53 Vitamin & Mineral Matrix.
Let’s examine some of the main ingredients in each category.
N53 Protein Blend
Milk Protein Isolate. Milk protein isolate is a combination of 80 percent casein and 20 percent whey protein. It is easily digestible and low in calories and sugar. 
Whey Protein Isolate. Whey protein isolate contains all nutritionally necessary amino acids. It also contains high levels of branched chain amino acids, which are metabolized into muscle tissue to promote muscle growth. 
N53 Fruit and Vegetable Blend
Fibersol. Fibersol is patented maltodextrin, a soluble corn fiber. Fiber is found to promote satisfaction with a low-calorie diet. 
Dehydrated Fruits and Veggies. Lean1 contains at least a dozen dried or dehydrated fruits and vegetables, including cranberries, broccoli, spinach, blueberries, and beets. Fruits and vegetables such as these add important nutrients to the diet and reduce disease risk.
N53 Vitamin and Mineral Matrix
The vitamin and mineral matrix contains many important nutrients, such as vitamin C, iron, zinc, calcium, and magnesium. In addition, it provides several weight-loss promoting ingredients, including the following:
Hoodia Gordonii. Though hoodia is said to curb appetite, one case report investigated hoodia weight loss claims, and remarked: “No published, peer-reviewed randomized controlled trials examining efficacy of Hoodia were found.” 
Green Coffee Bean Extract. One double-blind, placebo-controlled study found 16 subjects reduced body fat and weight by taking green coffee bean extract. But, results are still preliminary. 
Acai Berry. One study evaluated the effect of acai fruit pulp and found it reduced fasting glucose, insulin levels, and cholesterol. 
Nutrition 53 Lean1 Flavors
Lean1 comes in the following flavors:
• Cookies and Cream
• Banana Cream
Vanilla and chocolate seem to be the preferred flavors, or at least the ones that most customers have tried.
Nutrition 53 Lean1 Reception
Customer reviews on Amazon.com make it clear: people like Lean1. Out of 129 reviews of the vanilla flavor, 78 people gave it 5/5 stars.
Leonard Marasco praised its weight loss benefits, saying:
“I was a bit skeptical, but this supplement tastes great and I believe has aided in my weight loss. I do diet and exercise, so really it’s a mixture of everything. I take this in the morning and at noon; my hunger is satisfied and I’m getting plenty of nutrients. I think it’s fantastic. Getting ready to order more now!”
Caroline R. also hailed its nutritional benefits for athletes:
“As a runner, I have been evaluating many different nutritional supplements and have not until now found one that had a great balance of nutrition with great flavor. Lean1 has a roughly 30-40-30 fat to protein to carbohydrate ratio along with fiber to help satisfy hunger. It has a proprietary whey protein blend base like many other nutritional supplements but also includes a great blend of fruits and vegetables for added nutrition which I have not seen in other products. I have also found that Lean1 tastes a lot better than other popular protein shakes.”
However, the main reason why people did not like Lean1 was due to the flavor.
Edwin Kernan said, “Tastes like cr*p! Tried with water first, terrible. Tried with milk, insult to milk! Would love to benefit from the supposed fiber, protein etc. if I could force myself to consume this horrible tasting drink.”
However, others loved the flavor. Yayamom said, “It is like having a treat!”
Nutrition 53 Lean1 Pricing
A 2 lb. container of Lean1 containing between 10 and 15 servings costs $39.97 at Nutrition53.com. At about $3 per serving, this is pretty pricey for a weight loss shake.
You can buy it elsewhere, but the price isn’t much less and varies depending on the size and flavor. For example, a 2 lb. tub of the chocolate flavor is available at the following:
• $32.15 at Amazon.com
• $40.02 at iMedmart.com
Should You Buy Nutrition 53 Lean1?
Nutrition 53 Lean1 has a good amount of protein and nutrients, and when used as a meal replacement, it could promote weight loss.
However, it is expensive, so you’ll have to decide whether taking Lean1 is worth a knock to your wallet.
 “Sugars 101.” American Heart Association. Available from: http://www.heart.org/HEARTORG/GettingHealthy/NutritionCenter/Sugars-101_UCM_306024_Article.jsp
 Davita Parks. “What Is a Milk Protein Isolate?” LiveStrong.com. 14 June 2011. Available from: http://www.livestrong.com/article/289039-what-is-a-milk-protein-isolate/
 Doug Hewitt. “Benefits of Whey Protein Isolate.” LiveStrong.com 12 May 2011. Available from: http://www.livestrong.com/article/39242-benefits-whey-protein-isolate/
 Cheryl H. Gilhooly et al. “Use of cereal fiber to facilitate adherence to a human caloric restriction program.” Aging Clin Exp Res. 2008; 20 (6): 514-520. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869218/
 A.M. Whelan, PharmD et al. “Efficacy of Hoodia for weight loss: is there evidence to support the efficacy claims?” Journal of Clinical Pharmacy and Therapeutics. 2010; 35 (5): 609-612. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2009.01116.x/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false
 Joe A. Vinson et al. “Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.” Diabetes Metab Syndr Obes. 2012; 5: 21-27. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3267522/
 A.M. Whelan; T.M. Jurgens; V. Szeto. “Efficacy of Hoodia for weight loss: is there evidence to support the efficacy claims?” Journal of Clinical Pharmacy and Therapeutics. 2010; 35 (5): 609-612. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2009.01116.x/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false
Omega Sports BURN 24
Omega Sports claims to have made “a scientific breakthrough in fat loss” with its new fat burner, BURN 24.
By improving insulin sensitivity in cells, Omega Sports promises BURN 24 helps you “burn fat 24 hours a day.”
I researched the science behind Omega Sports’ insulin-based weight loss plan to see if it really works.
Omega Sports is a Missouri-based sports supplement company. Founded in 2004, the company has a reputation for quality products and has won the 2008 Planet Muscle award for top supplement.
While many supplement companies fail to provide any basic information about themselves, Omega Sports is pretty open. For example, the company’s website, OmegaSportsNutrition.com, lists the company’s business address and contact information.
Though Omega Sports only makes five different products, it appears to be an established company with a good reputation.
However, the fact doesn’t necessarily mean BURN 24 is an effective product. . .
The BURN 24 Formula
BURN 24’s formula consists of 7 ingredients Omega Sports claims lowers blood glucose and insulin levels, resulting in faster weight loss.
Green Coffee Bean Extract (250 mg) was found to promote weight loss in 16 overweight people during a 22-week study. Researchers believe this is because of green coffee bean’s high chlorogenic acid content, which lowers glucose and insulin concentrations.
However this study is too small to provide reliable results. Consequently, a larger study on about 60 people is planned to further understand green coffee bean’s effect on glucose and insulin.
Momordica Charantia Extract (200 mg) is known for its hypoglycemic effect. In a 2002 study, rats were fed a high-fat diet and given free-dried bitter melon (mormordica charantia) supplements. Researchers found rats given the bitter melon supplement gained less weight and had less fat than rats fed a just a high-fat diet.
At the end of the study, researchers attributed these results to mormordica charantia’s ability to lower insulin resistance.
While momordica charantia’s effect on rats is promising, human-based clinical research is lacking.
Berberine Hydrochloride (200 mg) is an alkaloid that stimulates insulin receptors. This, in turn, optimizes glucose consumption and utilization as well as insulin resistance.
Interestingly, norepinephrine appears to be effective in attaching to and burning visceral and omental fat cells, the fat beneath the skin and around the intestines. Consequently, norepinephrine-induced weight loss will likely result in a thinner waist and a leaner appearance.
Omega Sports claims bergenin also inhibits insulin’s ability to store fat, but clinical evidence is lacking.
Gymnema Sylvestre (150 mg) is clinically proven to lower blood glucose levels in 27 patients with insulin-dependent diabetes mellitus. Researchers believe this may be because gymnema sylvestre regenerated islets of Langerhans, resulting in more beta cells to produce insulin.
Cissus Quadrangularis (100 mg) lowers insulin resistance and increases glucose absorption. This results in lower blood glucose and a reduced risk of developing type 2 diabetes.
Piper Nigrum (6 mg) appears to fight fat gain by interfering with the activity of genes responsible for forming new fat cells.
Most BURN 24 ingredients appear effective in lowering insulin and glucose levels, resulting in more efficient fat burn. However, gymnema sylvestre, runs counteractive to BURN 24’s purported claims.
Consequently, BURN 24’s effectiveness is questionable.
People taking diabetic medication should stay clear of BURN 24. Most ingredients lower blood glucose levels and if taken with diabetic medication, can cause dangerously low blood glucose levels.
How to Use BURN 24
According to BURN 24’s official website, “Burn24 is best taken before meals. We recommend taking one serving before breakfast, one service before your mid-day meals, and one serving before your evening meal.”
One serving is 2 capsules, so don’t take more than 6 capsules a day.
Currently, BURN 24 can only be purchased online for approximately $40 per 180-capsule bottle. For example, Nutraplant.com and AllStarHealth.com sell one bottle for $39.99 plus shipping and handling.
Omega Sports claims to offer a 100% money-back guarantee but the company doesn’t provide much information about this guarantee. The website merely states, “If you purchased Burn24 through an online retailer or elsewhere, please contact that retailer and they will honor our money back guarantee.”
BURN 24 has a lot going for it. Many ingredients appear to be effective in lowering blood glucose levels. However, gymnema sylvestre may hinder the formula’s total effectiveness.
Also, there is no direct clinical evidence that improving insulin sensitivity will lead to better fat burn and weight loss.
$40 is a lot to spend on an unproven fat burner. I wouldn’t risk my money and health when there are other proven fat burners to choose from.
 Chen, Qixuan, et al. “Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet.” The Journal of Nutrition, 133.4 (2003): 1088-1093. http://jn.nutrition.org/content/133/4/1088.short
 Gu, Yan, et al. “Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics.” Talanta, 81.3 (2010): 766-772.
 Morimoto, C., T. Tsujita, and H. Okuda. “Norepinephrine-induced lipolysis in rat fat cells from visceral and subcutaneous sites: role of hormone-sensitive lipase and lipid droplets.” Journal of Lipid Research, 38.1 (1997): 132-138. http://www.ncbi.nlm.nih.gov/pubmed/9034207
 Chidambaram, Jaya, and Anuradha Carani Venkatraman. “< i> Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet.” Food and Chemical Toxicology, 48.8 (2010): 2021-2029. http://www.ncbi.nlm.nih.gov/pubmed/20450951
 Reaven, Gerald M. “Relationships among insulin resistance, type 2 diabetes, essential hypertension, and cardiovascular disease: similarities and differences.” The Journal of Clinical Hypertension, 13.4 (2011): 238-243. http://www.ncbi.nlm.nih.gov/pubmed/21466618
Designed by BeautyFit, BeautyCleanse is a fairly new supplement offering “natural daily detoxification.”
Environmental toxins in the air we breathe and the food we eat put our health and performance on the line. According to BeautyCleanse advertisements, this diet pill counteracts and eliminates these toxins without the use of laxatives.
Unlike other detoxification supplements, BeautyCleanse is designed to be used for 30 days rather than just 3-7. But does this mean it’s safer or more effective?
What Does It Offer?
According to advertisements, BeautyCleanse does each of the following:
• Support seven channels of elimination
• Promotes energy
• Increases antioxidant protection
• Encourages natural detoxification
This sounds pretty good at first, but does BeautyCleanse deliver? Let’s take a closer look to find out.
Rather than going in-depth on all 32 ingredients, here’s a quick breakdown of the key ingredients in each proprietary blend.
Proprietary Herbal Detox Blend
Parsley. Parsley is commonly used to treat urinary tract infections and kidney stones. It is rich in the antioxidant quercetin, which protects against harmful by-products known as free radicals. 
According to experts, quercetin acts like an antihistamine and anti-inflammatory, making it a potential tool for treating heart disease. 
Dandelion. Dandelion is a gentle laxative and diuretic. It stimulates bile flow to improve digestion and is a useful tool for eliminating excess water retention. Dandelion is also a rich source for vitamins A, B, C, and D, as well as minerals iron, potassium, and zinc. 
Turmeric. Turmeric is a popular digestive aid due to its abilities to treat stomach pain, diarrhea, intestinal gas, and heartburn. According to experts, it may even treat osteoarthritis when taken twice daily in 500 mg doses.  However, BeautyCleanse offers a fraction of the recommended dose.
Green Tea. Green tea contains high polyphenol, flavonoid, and catechin concentrations. These antioxidants not only eliminate harmful environmental toxins, but they also give metabolism a boost.
Studies show green tea rich in catechins lowers body fat and cholesterol, making it a potential tool for fighting obesity and cardiovascular disease. 
Proprietary Nutraceutical Blend
L-Glutamine. Glutamine transports nitrogen and carbon to different cells. It is necessary for protein synthesis and muscle recovery. 
Lycopene. Lycopene is a carotenoid antioxidant. It reduces free radical damage and is commonly taken to prevent heart disease. However, there is not enough evidence to confirm its effectiveness for this use. 
Resveratrol. Resveratrol is a potent antioxidant that eliminates harmful environmental toxins. Studies suggest resveratrol lowers blood pressure and liver fat, but is not a good replacement for diet and exercise. 
Proprietary BloatEase Blend
Ginger. Ginger is a both a digestive aid and a fat burner. Not only does it alleviate various conditions such as nausea and morning sickness but it also increases internal temperature to promote calorie burning. Preliminary studies suggest ginger also reduces appetite. 
Cayenne. Cayenne pepper contains the thermogenic chemical capsaicin which gives pepper its spicy taste. Experts believe cayenne has an appetite suppressing effect, but further research is needed to confirm preliminary study results. 
Peppermint. Peppermint calms stomach muscles and stimulates bile flow to improve digestion. Some studies suggest peppermint is an effective IBS (Irritable Bowel Syndrome) treatment, but results are fairly mixed. 
Black Pepper. Black pepper contains the chemical piperine, which enhances nutrient absorption. 
Should You Be Worried About Side Effects?
BeautyCleanse contains a mix of diuretics and laxatives. Although the concentrations are small, they may be strong enough to trigger nausea, diarrhea, constipation, cramping, and digestive upset.
Furthermore, many ingredients interact negatively with medications, so it’s best to consult your doctor prior to use.
Currently, the only BeautyCleanse review I could find was posted on BodyBuilding.com.
According to Stephanie Bili, “I take it every day!!! Helps with my gas & bloating from eating a diet rich in fiber!”
This sounds great at first, but a closer look reveals Stephanie Bili (or Billings) is part of team BeautyFit. She endorses BeautyFit products and blogs about her success with them.
This makes me question if BeautyCleanse’s results. If Beautycleanse is so effective, why does BeautyFit need to pay athletes to write a review?
Manufacturers recommend taking 2 capsules daily with an 8 oz. glass of water and a meal. For best results, take BeautyCleanse for at least 30 days in conjunction with a healthy diet and regular exercise.
Can You Stack BeautyCleanse?
BeautyCleanse is designed to jump-start a weight loss program, not provide long-term results. Consequently, it is often combined with other products to optimize weight loss.
BeautyFit recommends stacking BeautyCleanse with BeautyBurn AM-PM as well as BeautyComplex.
Product Price and Guarantee
Currently, BeautyFit sells 90-capsule bottles of BeautyCleanse for $26.99. However, if you buy the complete stack, it costs approximately $122.38 plus shipping.
This may seem a bit pricey at first, but it’s actually the best deal online. For example, BeautyCleanse can also be purchased at the following sites:
If you order directly from the manufacturers, you may return your product for a full refund within 30 days. Contact customer service at 954-530-6723 for more information.
Should You Try BeautyCleanse?
BeautyCleanse doesn’t seem like a bad product. Many ingredients are all-natural and backed with clinical research. The concentrations are small enough to reduce side effect risk, and the results are more gradual than most cleanses.
However, I can’t help but be skeptical of proprietary blends, and the lack of customer reviews is disconcerting. I suggest waiting for more information before investing in BeautyCleanse.
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 Nagao T, Hase T, Tokimitsu I. “A green tea extract high in catechins reduces body fat and cardiovascular risks in humans.” Obesity (Silver Spring). 2007 Jun;15(6):1473-83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17557985
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 Moisse, Katie. “Red Wine Ingredient Resveratrol mimics Diet, Exercise in Obese Men.” ABC News. Nov 1, 2011. Available from: http://abcnews.go.com/Health/w_DietAndFitnessNews/red-wine-ingredient-resveratrol-mimics-calorie-restriction-obese/story?id=14852698#.UXBuqBxJObM
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GNC Total Lean CLA PM
GNC Total Lean CLA PM has several functions: promote restful and restorative sleep, improve body composition, and optimize muscle tone.
The conjugated linoleic acid (CLA) in GNC Total Lean CLA is touted to decrease abdominal fat. And, the natural herbs supposedly promote a good night’s sleep.
GNC Total Lean CLA PM isn’t the first diet pill claiming to promote both sleep and weight loss. So how does it fare? Let’s take a closer look.
GNC: The Company
GNC is a company that sells hundreds of products, both of their own manufacturing and from other companies. If you’re looking for a health supplement, chances are you’ll find it at GNC.
According to the website, “GNC sets the standard in the nutritional supplement industry by demanding truth in labeling, ingredient safety and product potency, all while remaining on the cutting-edge of nutritional science.” On their website, you will find detailed nutritional information on each product.
GNC also offers Total Lean CLA, which features CLA as the main ingredient. Let’s see if adding sleep aids adds some oomph to GNC Total Lean CLA PM.
GNC Total Lean CLA PM Ingredients
The following ingredients give GNC Total Lean CLA PM its potency:
CLA (3.4 g). CLA is currently being studied for numerous purported benefits, including its ability to increase metabolic rate, enhance muscle growth, lower insulin resistance, and even decrease abdominal fat. It supposedly treats thyroid problems and thereby reduces abdominal fat accumulation caused by hormone imbalances. 
In one study, CLA supplementation reduced body mass index and abdominal fat without altering lean mass. This shows some promising benefits indeed. 
CLA is safe to use, but some believe long-term use increases insulin resistance and type 2 diabetes risk
Rest and Relaxation Complex
Valerian Root Extract (100 mg). Valerian extract improved sleep structure and perception in insomnia patients in one double-blind cross-over study.  Valerian is thought to be safe but may cause headache, uneasiness, and even insomnia in some. 
WebMD.com lists 400 to 900 mg valerian for 28 days as an effective dosage. GNC Total Lean CLA PM provides 400 mg in the 4 capsules recommended per day.
L-Theanine (50 mg). 400 mg theanine daily for six weeks improved sleep percentage and efficiency in boys with ADHD. It was also well tolerated, with no significant adverse events.  CLA PM offers 200 mg theanine per daily dose.
Lemon Balm Leaves Extract (50 mg). Lemon balm has a calming effect that reduces anxiety and restlessness. However, it also causes nausea, abdominal pain, and dizziness in some.  Subjects treated with a valerian/lemon balm combination improved sleep quality with no serious adverse events. 
According to WebMD.com, an effective dose for improving sleep is 80 mg lemon balm and 160 mg valerian 3 times daily for 30 days, which is slightly more than the amount in CLA PM.
Hops Flower Extract (50 mg). A 500 mg valerian and 120 mg hops supplement reduced sleep latency, while valerian on its own had no effect.  CLA PM features slightly less valerian and slightly more hops than this dosage.
Passion Flower Herb Powder (50 mg). Subjects rated sleep quality higher when they took a low passionflower dose each day for a week. 
Passionflower is likely safe, but could cause dizziness, irregular muscle action, and inflamed blood vessels, particularly when used long-term or in large amounts. A 90 mg/day tablet has been used to reduce anxiety, but the proper dose for sleep is unknown. 
Restore and Recover Complex
Gelatin (50 mg). Gelatin improves exercise recovery and strengthens bones.  In one study, a breakfast containing gelatin improved satiety and reduced food intake. 
Alpha Lipoic Acid (10 mg). Alpha lipoic acid may treat certain metabolic syndrome factors. In one study, rabbits fed a high-cholesterol diet combined with alpha lipoic acid decreased body weight and reduced lipid content. 
L-Methionine (10 mg). This amino acid helps your liver turn fat-soluble toxins into water-soluble waste. 
Silica (4 mg). Silica is needed in small amounts, but long-term use could cause thiamine deficiency, dehydration, or kidney trouble. 
Horsetail Rush Stems Extract (3 mg). This plant functions as a diuretic, flushing excess water weight. A standard dose is 1 g taken 3 times daily. But, horsetail contains silica, and thus carries the same side effects. 
Boron (2 mg). Boron is said to boost testosterone and aid muscle building, but this is not proven in studies. 
Lutein (950 mcg). Lutein improves vision and is safe to use. 
CLA PM Dosage
Take 4 softgel capsules at bedtime.
Side effect risk is fairly low, but some ingredients could cause side effects such as nausea and dizziness. Taking CLA PM long-term may cause larger problems due to silica content.
CLA PM Reviews
Only two reviews are available at GNC.com. Because they are found on GNC’s website, it’s a bit hard to trust their reliability.
In any case, hherland said, “I take three capsules about an hour before bedtime. It seems to relax me and I get a good night’s sleep. I was able to discontinue a different sleep product I had been taking.”
GNC Total Lean CLA PM: The Final Word
GNC Total Lean CLA PM offers a good ingredient selection, with ingredients at proper dosages. However, there aren’t enough customer reviews to allow us to make a final judgment call.
If you decide to buy CLA PM, you can find it at the following locations and prices:
• GNC.com: $39.99
• Amazon.com: $31.95
For now, though, you may want to choose something that’s popular among consumers.
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 Veldhorst MA. “A breakfast with alpha-lactalbumin, gelatin, or gelatin + TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or whey-GMP.” Clin Nutr. 2009; 28 (2): 147-55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19185957
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